医学統計学研究センターロゴ文字
医学統計学の正しい知識と理解の普及を図るための研究・教育・啓蒙活動を行うとともに
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  研究者氏名         丹後俊郎 (Toshiro Tango)
  取得学位名         医学博士、工学修士
  所属学会名         American Statistical Association, The Royal Statistical Society, The Biometric Society,
        International Society for Clinical Biostatistics, 日本計量生物学会、応用統計学会、日本統計学会、
        日本公衆衛生学会、日本医療情報学会
  現在の専門分野         医学統計学、理論疫学
  現在の研究課題         疾病集積性の研究、希少発生疾患のサーベイランスに関する研究、臨床試験のデザインと統計解析に関する
        研究、環境汚染の健康影響に関する研究、他
  主要著書
主要な統計手法の提案
  • 疾病の空間集積性を検定しかつ集積地域を推定する方法 ＜プログラムFleXScan＞
    　　（Tango and Takahashi, International Journal of Health Geographics 2005; 4: 11）

  • 未知数が確率変数である場合の線形（連立）方程式の推定法
    　　(Tango, Statistics in Medicine 2005; 24: 3213-3222. )

  • ごみ焼却施設、原子力発電などの周辺における健康影響を評価する統計的検定
    　　(Tango, Statistics in Medicine. 2002; 21:497-514 )

  • 疾病の空間（地域）集積性の検定法 ＜S-Plusプログラム＞
    　　(Tango, Statistics in Medicine. 2000; 19:191-204）
    　　(Tango, Statistics in Medicine, 1995;14: 2323-2334)

  • 対応のある比率の同等性の検定法＜Fortranプログラム＞
    　　 (Tango, Statistics in Medicine, 2000; 19: 133-139)
    　　 (Tango, Statistics in Medicine, 1998; 17:891-908)

  • 栄養教育のための半定量食物摂取頻度調査票の妥当性と再現性の検討法
    　　(山岡、丹後、渡辺、 日本公衛誌、2000; 47: 230-244).

  • 標準化死亡比、調整死亡率などの人口動態統計指標の経験的ベイズ推定法
    　　(丹後、癌の臨床, 1999; 45: 1253-1260 ).
    　　(丹後、公衆衛生研究、1999; 48: 84-93 ).
    　　(丹後、応用統計学, 1988; 17: 81-96)

  • 対数正規分布を仮定した食中毒曝露時点の最尤推定法 ＜S-Plus プログラム＞
    　　(丹後、日本公衆衛生雑誌, 1998; 45: 129-141)

  • 臨床検査・成長指標などの年齢によって変動する規準範囲の推定法 ＜S-Plus プログラム＞
    　　(Tango, Statistics in Medicine、1998; 17:1231-1243)

  • 経時的測定データの混合モデルによる解析法
    　　(Tango, Data Science, Classification and Related Topics, C. Hayashi, et al. Ed., Springer-Verlag, Tokyo,1998: 247-254)
    　　(丹後、応用統計学、1989; 18, 143-161)

  • 対応のない比率のMantel-Haensze 型臨床的同等性（非劣性）の検定.
    　　(Yanagawa, Tango, Hiejima, Biometrics、1994; 50: 859-864)

  • 大気汚染の健康影響の方法論
    　　(Tango, Environment Health Perspective, 1994; 102: 41-45)
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  最近の主要研究業績
  • Tango T, Takahashi K and Kohriyama K. A space-time scan statistic for detecting emerging outbreaks. Biometrics 2011; 67: 106-115.

  • Zushi M, Yamaoka K, Watanabe M and Tango T. Development of a statistical metabolic syndrome simulator. Japanese Journal of Public Health 2010;  57: 1043-1053.
  • Adachi M, Yamaoka K, Watanabe M, Nishikawa M, Hida E, Kobayashi I and Tango T.  Effects of lifestyle education program for type 2 diabetes patients in clinics: study design of a cluster randomized trial. BMC Public Health  2010; 10:742  (http://www.biomedcentral.com/1471-2458/10/742 )
  • Hida, E. and Tango T.  On the three-arm non-inferiority trial including  a placebo with a prespecified margin. Statistics in Medicine 2011; 30: 224-231
  • Yamaoka K, Watanabe M, Hida E and Tango T.  Impact of group based dietary education on dietary habit for female adolescents: A cluster randomized trial.  Public Health Nutrition  2010; 14: 702-708.
  • Takahashi K. and Tango T.  Assignment of grouped exposure levels for trend estimation in a regression analysis of summarized data.  Statistics in Medicine  2010; 29: 2605–2616.
  • Watanabe, M, Yamaoka K,  Adachi M, Yokotsuka M, Tango T.  Validity and Reproducibility of the Food Frequency Questionnaire (FFQW82) for Dietary Assessment in Female Adolescents.  Public Health Nutrition 2010; 14: 297-305
  • Sumi M and Tango T. Inference on the rate ratio of recurrent events for the matched pairs design.　Statistics in Medicine  2010; 29: 3186-3193
  • 高橋邦彦, 飛田英祐, 山岡和枝, 丹後俊郎.  ベイズ推定の医療費地域差指数への適用.  日本公衆衛生雑誌　2010, 57:17-26. 
  • Nishikawa M, Tango T. Ohtaki M. Statistical tests based on new composite hypotheses in clinical trials reflecting the relative clinical importance of multiple endpoints quantitatively. Biometrical Journal 2009; 51:749-762.

  • Tango T. Sample size formula for randomized controlled trials with counts of recurrent events. Statistics and Probability Letters. 2009; 79: 466-472.

  • Hasegawa T, Tango T. Permutation test following covariate-adaptive randomization in randomized controlled trials. Journal of Biopharmaceutical Statistics, 2009; 19: 106-119.

  • Tango T. A spatial scan statistic with a restricted likelihood ratio. Japanese Journal of Biometrics 2008; 29:75-95.

  • Ishizuka B, Kudo Y, Tango T. Cross-sectional community survey of menopause symptoms among Japanese women. Maturitas, 2008; 61: 260-267.

  • Takahashi K, Kulldorff M, Tango T and Yih K. A flexibly shaped space-time scan statistic for disease outbreak detection and monitoring. International Journal of Health Geographics 2008; 7:14.

  • Doi Y, Yokoyama T, Sakai M, Nakamura Y, Tango T and Takahashi K. Spatial clusters of Creutzfeldt-Jakob disease mortality in Japan between 1995 and 2004. Neuroepidemiology 2008; 30:222-228.

  • Tango T. A class of multiplicity-adjusted tests for spatial clustering based on case-control point data, Biometrics, 2007; 63: 119-127.

  • Mitani S, Kamata H, Fujiwara M, Aoki N, Okada S, Watanabe M, Tango T and Mori S. Missense mutation with/without nonsense mutation of the p53 gene is associated with large cell morphology in human malignant lymphoma. Pathology International, 2007; 57: 430-436.

  • Takahashi K and Tango T. An extended power of cluster detection tests. Statistics in Medicine 2006; 25: 841-852.

  • Nishikawa M, Tango T, Ogawa M. Non-Parametric inference of adverse events under informative censoring. Statistics in Medicine, 2006; 25: 3981-4003.

  • Nishikawa M and Tango T. Letter to the editor - "Testing treatment effects in the presence of competing risks. Statistics in Medicine, 2006; 25: 3758-3760.

  • Aida J, Ando Y, Aoyama H, Tango T, Morita M. An ecological study on the association of public dental health activities and sociodemographic characteristics with caries prevalence in Japanese 3-year-old children. Caries Research, 2006; 40: 466-472.

  • Tango T. Linear equations with random variables. Statistics in Medicine. 2005; 24: 3213-3222.

  • Yamaoka K and Tango T. Efficacy of lifestyle education to prevent type 2 diabetes - A meta-analysis of randomized controlled trials. Diabetes Care. 2005; 28: 2780-2786.

  • Tango T and Takahashi K. A flexibly shaped spatial scan statistic for detecting clusters. International Journal of Health Geographics. 2005; 4: 11.

  • Tango T, Fujita T, Tanihata T, Minowa M, Doi Y, Kato N, Kunikane S, Uchiyama I, Tanaka M and Uehata T. Risk of adverse reproductive outcomes associated with proximity to municipal solid waste incinerators with high dioxin emission levels in Japan. Journal of Epidemiology. 2004; 14: 83-93.

  • Watanabe M, Yamaoka K, Yokotsuka M, Tango T. Randomized controlled trial of a new dietary education program to prevent type 2 diabetes in a high-risk group of Japanese male workers, Diabetes Care. 2003; 26：3209-3214.

  • Nishikawa M and Tango T. Counter-intuitive Properties of the Kaplan-Meier Estimator. Statistics and Probability Letters. 2003; 65: 353-361.

  • Nishikawa M and Tango T. Behavior of the Kaplan-Meier Estimator for deterministic imputations to interval-censored data and the Turnbull estimator. Japanese Journal of Biometrics. 2003; 24(2):71-94.

  • Kulldorff M, Tango T and Park PJ. Power comparisons for disease clustering tests. Computational Statistics and Data Analysis 2003; 42: 665-684.

  • Doi Y, Minowa M, Tango, T. Impact and correlates of poor sleep quality in Japanese white-color employees. Sleep. 2003; 26: 467-471.

  • Kawashima M, Tango, T, Noguchi T, Inagi M, Nakagawa H and Harada S. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicenter, double-blind, placebo-controlled, parallel-group study. British Journal of Dermatology. 2003; 148: 1212-1221.

  • Iwasaki, T, Murata M, Ohshima S, Miyake T, Kudo S, Inoue Y, Narita M, Yoshimura T, Akiba S, Tango T, Yoshimoto Y, Shimizu Y, Sobue T, Kusumi S, Yamagishi C and Matsudaira H. Second analysis of mortality of Nuclear Industry workers in Japan, 1986-1997. Radiation Rsearch. 2003; 159:228-238.

  • Daida H, Ouchi Y, Saito Y, Yamada N, Nishide T, Mokuno H, Kurata T, Sato H, Eto M, Ako J, Tango T. and Yamaguchi H. Preventing angiograhic progression of coronary atherosclerosis with pravastatin. Journal of Atherosclerosis and Thrombosis. 2003: 10: 25-31.

  • Tango T. Score tests for detecting excess risks around putative sources. Statistics in Medicine. 2002; 21: 497-514.

  • Murata M, Miyake T, Inoue Y, Ohshima S, Kudo S, Yoshimura T, Akiba S, Tango T, Yoshimoto Y, Shimizu Y, Sobue T, Kusumi S, Iwasaki T, Yamagishi C and Matsudaira H. Life-style and other characteristics of radiation workers at nuclear facilities in Japan: Base-line data of a questionnaire survey. J. Epidemiology. 2002; 12: 310-319.

  • Miyake K, Tango, T, Ota Y, Mitamura K, Yoshiba M, Kako M, Hayashi S, Ikeda Y, Hayashida N, Iwabuchi S, Sato Y, Tomi T, Funaki N, Hashimoto N, Umeda T, Miyazaki J, Tanaka K, Endo Y and Suzuki H. Efficacy of stronger neo-minophagen between two doses administered three times a week on patients with chronic viral hepatitis. J. Gatroenterology and Hepatology. 2002; 17: 1198-1204.

  • Kawashima M, Harada S and Tango T. Review of fexofenadine in the treatment of chronic idiopathic urticaria. The International Journal of Dermatology. 2002; 41: 701-706.

  • Takahashi M and Tango T. Estimation of excess mortality associated with influenza-epidemics by age and cause specific death in Japan, 1975-1999. Japanese Journal of Hygine. 2002; 57: 571-584 (in Japanese).

  • Iino S, Tango T, Matsushima T, Toda G, Miyaka K, Hino K, Kumada H, Yasuda, K, Kuroki T, Hirayama C and Suzuki H. Therapeutic effects of stronger neo-minophagen C at different doses on chronic hepatitis and liver cirrhosis. Hepatology Research. 2001; 19: 31-40.

  • Mitani S, Kamata H, Fujiwara M, Aoki N, Tango T, Fukuchi K, Oka T. Analysis of c-myc DNA amplification in non-small cell lung carcinoma in comparison wiht small cell lung carcinoma using polymerase chain reaction. Clin Exp Med. 2001; 2: 105-111.

  • Takahashi M and Tango T. Comparison study of new method and the Kawai and Fukutomi methods for estimating excess mortality associated with influenza-epidemics, based upon National vital statistics from 1975 to 1997. Japanese Journal of Public Health. 2001; 48: 816-826 (in Japanese).

  • Takahashi M and Tango T. A proposal for a new definition of excess mortality associated with influenza-epidemics and its estimation. Japanese Journal of Public Health. 2001; 48: 402-408 (in Japanese).

  • Tango T. Confidence intervals for differences in correlated binary proportions (with Author's Reply). Statistics in Medicine. 2000; 19, 133-139.

  • Tango T. A test for spatial disease clustering adjusted for multiple testing. Statistics in Medicine. 2000; 19: 191-204.

  • Mori H, Taketani Y, Uemura T, Miyake A, and Tango T. Rates of endometriosis recurrence and pregnancy 1 year after treatment with intranasal Buserelin Acetate (A prospective study). J. Obstet. Gynaecol. Res. 1999; 25: 153-164.

  • Tango T. Comparison of general tests for disease clustering. in "Disease Mapping and Risk Assessment for Public Health (Lawson A. et al. eds), John Wiley & Sons, 1999; 111-117.

  • Tango T. Improved confidence intervals for the difference between binomial proportions based on paired data (with Author's Reply). Statistitics in Medicine. 1999; 18, 3511-3513.

  • Tango T. Equivalence test and confidence interval for the difference in proportions for the paired-sample design. Statistics in Medicine. 1998; 17: 891-908.

  • Tango T. Estimation of age-specific reference ranges via smoother AVAS. Statistics in Medicine. 1998; 17: 1231-1243.

  • Tango T. A mixture model to classify individual profiles of repeated measurements. In "Data Science, Classification and Related Topics (eds by C. Hayashi, et al.), Springer-Verlag, Tokyo, 1998; 247-254.

  • Tango T. Adjusting Moran's I for population density. Statistics in Medicine. 1998; 17: 1055-1062.

  • Tango T, Maximum likelihood estimation of date of infection in an outbreak of diarrhea due to contaminated foods assuming lognormal distribution for the incubation period. Japanese Journal of Public Health. 1998; 45: 129-141
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